VALVES USED IN BIOPROCESS INDUSTRY

VALVES

A valve is a mechanical device that controls the flow of fluid and pressure within a system or process.

A valve controls system or process fluid flow and pressure by
• Stopping and starting fluid flow
• Varying (throttling) the amount of fluid flow
• Controlling the direction of fluid flow
• Regulating downstream system or process pressure
• Relieving component or piping over pressure.

The valves are also determined as Automatic and Manual valves based on the system and requirements.

Specification for valves in BioProcess is based on
• Aseptic operation
• Non-sterile operation
• Utility area operation

Features acceptable in BioProcess
• Sterilisable
• Zero dead leg
• Low product hold
• Total drainability

DESIGN REQUIREMENT– ASME BPE
• Valves for hygienic application must be welded into process lines
• The valves must be readily accessible for inspection, cleaning & maintenance
• All cavities within the valve must be accessible for CIP solution & SIP

Surface Finish requirements of Valves in Bioprocess

TYPES OF VALVES USED IN BIOPROCESS

Direct Product Contact Lines:
• Diaphragm valve
• Flush bottom valve
• Sampling valve
• Sterile safety relief valve

Indirect product contact/ Process /Utility Lines:

• Needle valve
• Pressure regulating valve
• Non-Return valve
• Angle seat valve
• Ball valve
• Safety relief valve
• Butter fly valve
• Globe / Gate valve

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